CD206-Targeted Liposomal Myelin Basic Protein Peptides in Patients with Multiple Sclerosis Resistant to First-Line Disease-Modifying Therapies: A First-in-Human, Proof-of-Concept Dose-Escalation Study

Previously, we showed that CD206-targeted liposomal delivery of co-encapsulated immunodominant myelin basic protein (MBP) sequences MBP(46–62), MBP(124–139) and MBP(147–170) (Xemys) suppressed experimental autoimmune encephalomyelitis in dark Agouti rats. The objective of this study was to assess th...

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Veröffentlicht in:Neurotherapeutics
Hauptverfasser: Belogurov, Alexey, Zakharov, Konstantin, Lomakin, Yakov, Surkov, Kirill, Avtushenko, Sergey, Kruglyakov, Peter, Smirnov, Ivan, Makshakov, Gleb, Lockshin, Curtis, Gregoriadis, Gregory, Genkin, Dmitry, Gabibov, Alexander, Evdoshenko, Evgeniy
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer US 2016
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081122/
https://ncbi.nlm.nih.gov/pubmed/27324388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-016-0448-0
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