Combined Metabolomics and Transcriptomics Approaches to Assess the IL-6 Blockade as a Therapeutic of ALS: Deleterious Alteration of Lipid Metabolism

In amyotrophic lateral sclerosis (ALS), motor neuron degeneration occurs simultaneously with systemic metabolic impairment and neuroinflammation. Playing an important role in the regulation of both phenomena, interleukin (IL)-6, a major cytokine of the inflammatory response has been proposed as a ta...

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Bibliografske podrobnosti
izdano v:Neurotherapeutics
Main Authors: Patin, Franck, Baranek, Thomas, Vourc’h, Patrick, Nadal-Desbarats, Lydie, Goossens, Jean-François, Marouillat, Sylviane, Dessein, Anne-Frédérique, Descat, Amandine, Hounoum, Blandine Madji, Bruno, Clément, Watier, Hervé, Si-Tahar, Mustafa, Leman, Samuel, Lecron, Jean-Claude, Andres, Christian R., Corcia, Philippe, Blasco, Hélène
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2016
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081117/
https://ncbi.nlm.nih.gov/pubmed/27444617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-016-0461-3
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