Dysregulations of Expression of Genes of the Ubiquitin/SUMO Pathways in an In Vitro Model of Amyotrophic Lateral Sclerosis Combining Oxidative Stress and SOD1 Gene Mutation

Protein aggregates in affected motor neurons are a hallmark of amyotrophic lateral sclerosis (ALS), but the molecular pathways leading to their formation remain incompletely understood. Oxidative stress associated with age, the major risk factor in ALS, contributes to this neurodegeneration in ALS....

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Dangoumau, Audrey, Marouillat, Sylviane, Coelho, Roxane, Wurmser, François, Brulard, Céline, Haouari, Shanez, Laumonnier, Frédéric, Corcia, Philippe, Andres, Christian R., Blasco, Hélène, Vourc’h, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7918082/
https://ncbi.nlm.nih.gov/pubmed/33670299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22041796
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