Dysregulations of Expression of Genes of the Ubiquitin/SUMO Pathways in an In Vitro Model of Amyotrophic Lateral Sclerosis Combining Oxidative Stress and SOD1 Gene Mutation

Protein aggregates in affected motor neurons are a hallmark of amyotrophic lateral sclerosis (ALS), but the molecular pathways leading to their formation remain incompletely understood. Oxidative stress associated with age, the major risk factor in ALS, contributes to this neurodegeneration in ALS....

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Publicat a:Int J Mol Sci
Autors principals: Dangoumau, Audrey, Marouillat, Sylviane, Coelho, Roxane, Wurmser, François, Brulard, Céline, Haouari, Shanez, Laumonnier, Frédéric, Corcia, Philippe, Andres, Christian R., Blasco, Hélène, Vourc’h, Patrick
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7918082/
https://ncbi.nlm.nih.gov/pubmed/33670299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22041796
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