The debated toxic role of aggregated TDP-43 in amyotrophic lateral sclerosis: a resolution in sight?

Transactive response DNA-binding protein-43 (TDP-43) is an RNA/DNA binding protein that forms phosphorylated and ubiquitinated aggregates in the cytoplasm of motor neurons in amyotrophic lateral sclerosis, which is a hallmark of this disease. Amyotrophic lateral sclerosis is a neurodegenerative cond...

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Udgivet i:Brain
Main Authors: Hergesheimer, Rudolf C, Chami, Anna A., de Assis, Denis Reis, Vourc’h, Patrick, Andres, Christian R., Corcia, Philippe, Lanznaster, Débora, Blasco, Hélène
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Review Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6487324/
https://ncbi.nlm.nih.gov/pubmed/30938443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awz078
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