Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism

The retinoblastoma binding protein KDM5A removes methyl marks from lysine 4 of histone H3 (H3K4). Misregulation of KDM5A contributes to the pathogenesis of lung and gastric cancers. In addition to its catalytic jumonji C domain, KDM5A contains three PHD reader domains, commonly recognized as chromat...

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Udgivet i:Nat Commun
Main Authors: Torres, Idelisse Ortiz, Kuchenbecker, Kristopher M., Nnadi, Chimno I., Fletterick, Robert J., Kelly, Mark J.S., Fujimori, Danica Galonić
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5080983/
https://ncbi.nlm.nih.gov/pubmed/25686748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7204
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