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Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism
The retinoblastoma binding protein KDM5A removes methyl marks from lysine 4 of histone H3 (H3K4). Misregulation of KDM5A contributes to the pathogenesis of lung and gastric cancers. In addition to its catalytic jumonji C domain, KDM5A contains three PHD reader domains, commonly recognized as chromat...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5080983/ https://ncbi.nlm.nih.gov/pubmed/25686748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7204 |
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