Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism

The gut microbiota modulates obesity and associated metabolic phenotypes in part through intestinal farnesoid X receptor (FXR) signaling. Glycine-β-muricholic acid (Gly-MCA), an intestinal FXR antagonist, has been reported to prevent or reverse high-fat diet (HFD)-induced and genetic obesity, insuli...

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Publicado en:mSystems
Autores principales: Zhang, Limin, Xie, Cen, Nichols, Robert G., Chan, Siu H. J., Jiang, Changtao, Hao, Ruixin, Smith, Philip B., Cai, Jingwei, Simons, Margaret N., Hatzakis, Emmanuel, Maranas, Costas D., Gonzalez, Frank J., Patterson, Andrew D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2016
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5080402/
https://ncbi.nlm.nih.gov/pubmed/27822554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSystems.00070-16
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