A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro.

In earlier studies, we provided statistical evidence that individual differences in the angiotensinogen gene, the precursor of the vasoactive hormone angiotensin II, constitute inherited predispositions to essential hypertension in humans. We have now identified a common variant in the proximal prom...

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Bibliografische gegevens
Gepubliceerd in:J Clin Invest
Hoofdauteurs: Inoue, I, Nakajima, T, Williams, C S, Quackenbush, J, Puryear, R, Powers, M, Cheng, T, Ludwig, E H, Sharma, A M, Hata, A, Jeunemaitre, X, Lalouel, J M
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 1997
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Research Article
Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508000/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9120024/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119343
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