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Palladium-Catalyzed C(sp(3))–H Arylation of N-Boc Benzylalkylamines via a Deprotonative Cross-Coupling Process
Diarylmethylamines are key intermediates and products in the pharmaceutical industry. Herein we disclose a novel method toward the synthesis of these important compounds via C–H functionalization. Presented is a reversible deprotonation of N-Boc benzylalkylamines at the benzylic C–H with in situ ary...
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| Gepubliceerd in: | Chemistry |
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| Hoofdauteurs: | , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5079650/ https://ncbi.nlm.nih.gov/pubmed/26129922 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201502017 |
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