Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension.

The human endothelin-1 (ET-1) gene under the control of its natural promoter was transferred into the germline of mice. The transgene was expressed predominantly in the brain, lung, and kidney. Transgene expression was associated with a pathological phenotype manifested by signs such as age-dependen...

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Bibliografiske detaljer
Main Authors: Hocher, B, Thöne-Reineke, C, Rohmeiss, P, Schmager, F, Slowinski, T, Burst, V, Siegmund, F, Quertermous, T, Bauer, C, Neumayer, H H, Schleuning, W D, Theuring, F
Format: Artigo
Sprog:Inglês
Udgivet: 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC507954/
https://ncbi.nlm.nih.gov/pubmed/9077548
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