LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice.

To better define the specific function of Mac-1 (CD11b) versus LFA-1 (CD11a) and the other CD11 integrins in vivo, we have disrupted murine CD11b by targeted homologous recombination in embryonic stem cells and generated mice which are homozygous for a mutation in CD11b. A null mutation was confirme...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Lu, H, Smith, C W, Perrard, J, Bullard, D, Tang, L, Shappell, S B, Entman, M L, Beaudet, A L, Ballantyne, C M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1997
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507950/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9077544/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119293
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