Runx2 deletion in smooth muscle cells inhibits vascular osteochondrogenesis and calcification but not atherosclerotic lesion formation

AIMS: Vascular smooth muscle cells (SMCs) are major precursors contributing to osteochondrogenesis and calcification in atherosclerosis. Runt-related transcription factor-2 (Runx2) has been found essential for SMC differentiation to an osteochondrogenic phenotype and subsequent calcification in vitr...

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Publicado en:Cardiovasc Res
Autores principales: Lin, Mu-En, Chen, Theodore M., Wallingford, Mary C., Nguyen, Ngoc B., Yamada, Shunsuke, Sawangmake, Chenphop, Zhang, Jaimei, Speer, Mei Y., Giachelli, Cecilia M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2016
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5079276/
https://ncbi.nlm.nih.gov/pubmed/27671804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvw205
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