Runx2 Expression in Smooth Muscle Cells Is Required for Arterial Medial Calcification in Mice

Arterial medial calcification (AMC) is a hallmark of aging, diabetes, and chronic kidney disease. Smooth muscle cell (SMC) transition to an osteogenic phenotype is a common feature of AMC, and is preceded by expression of runt-related transcription factor 2 (Runx2), a master regulator of bone develo...

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Bibliografiska uppgifter
I publikationen:Am J Pathol
Huvudupphovsmän: Lin, Mu-En, Chen, Theodore, Leaf, Elizabeth M., Speer, Mei Y., Giachelli, Cecilia M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Investigative Pathology 2015
Ämnen:
Regular Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484217/
https://ncbi.nlm.nih.gov/pubmed/25987250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.03.020
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