Oral tolerization to adenoviral antigens permits long-term gene expression using recombinant adenoviral vectors.

Recombinant adenoviruses (Ads) efficiently transfer foreign genes into hepatocytes in vivo, but the duration of transgene expression is limited by the host immune response which precludes gene expression upon readministration of the virus. To test if this immune response can be abrogated by oral tol...

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Autores principales: Ilan, Y, Prakash, R, Davidson, A, Jona, Droguett, G, Horwitz, M S, Chowdhury, N R, Chowdhury, J R
Formato: Artigo
Lenguaje:Inglês
Publicado: 1997
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC507919/
https://ncbi.nlm.nih.gov/pubmed/9062369
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