Induction of central tolerance by intrathymic inoculation of adenoviral antigens into the host thymus permits long-term gene therapy in Gunn rats.

Recombinant adenoviruses are highly efficient at transferring foreign genes in vivo. However, duration of gene expression is limited by the host antiviral immune response which precludes expression upon viral readministration. We tested the feasibility of prolonging gene expression by induction of c...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Ilan, Y, Attavar, P, Takahashi, M, Davidson, A, Horwitz, M S, Guida, J, Chowdhury, N R, Chowdhury, J R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507724/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8958229/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119085
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