C9orf72 dipeptide repeats impair the assembly, dynamics and function of membrane-less organelles

Expansion of a hexanucleotide repeat GGGGCC (G(4)C(2)) in C9ORF72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Transcripts carrying (G(4)C(2)) expansions undergo unconventional, non-ATG-dependent translation, generating toxic dipeptide repeat (DP...

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Pubblicato in:Cell
Autori principali: Lee, Kyung-Ha, Zhang, Peipei, Kim, Hong Joo, Mitrea, Diana, Sarkar, Mohona, Freibaum, Brian, Cika, Jaclyn, Coughlin, Maura, Messing, James, Molliex, Amandine, Maxwell, Brian, Kim, Nam Chul, Temirov, Jamshid, Moore, Jennifer, Kolaitis, Regina-Maria, Shaw, Timothy, Bai, Bing, Peng, Junmin, Kriwacki, Richard, Taylor, J. Paul
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5079111/
https://ncbi.nlm.nih.gov/pubmed/27768896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.10.002
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