Anticancer Drug Released from Near IR-activated Prodrug Overcomes Spatiotemporal Limits of Singlet Oxygen

Photodynamic therapy (PDT) is a cancer treatment modality where photosensitizer (PS) is activated by visible and near IR light to produce singlet oxygen ((1)O(2)). However, (1)O(2) has a short lifetime (< 40 ns) and cannot diffuse (< 20 nm) beyond the cell diameter (e.g., ~ 1,800 nm). Thus, (1...

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Vydáno v:Bioorg Med Chem
Hlavní autoři: Rajaputra, Pallavi, Bio, Moses, Nkepang, Gregory, Thapa, Pritam, Woo, Sukyung, You, Youngjae
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078988/
https://ncbi.nlm.nih.gov/pubmed/26928287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.02.025
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