Cell-to-cell transmission of dipeptide repeat proteins linked to C9orf72-ALS/FTD

Aberrant hexanucleotide repeat expansions in C9orf72 are the most common genetic change underlying amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). RNA transcripts containing these expansions undergo repeat associated non-ATG (RAN) translation to form five dipeptide repeat prot...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Westergard, Thomas, Jensen, Brigid K., Wen, Xinmei, Cai, Jingli, Kropf, Elizabeth, Iacovitti, Lorraine, Pasinelli, Piera, Trotti, Davide
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078984/
https://ncbi.nlm.nih.gov/pubmed/27732842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.09.032
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