Treatment with Dexamethasone and Monophosphoryl Lipid A Removes Disease-Associated Transcriptional Signatures in Monocyte-Derived Dendritic Cells from Rheumatoid Arthritis Patients and Confers Tolerogenic Features

Tolerogenic dendritic cells (TolDCs) are promising tools for therapy of autoimmune diseases, such as rheumatoid arthritis (RA). Here, we characterize monocyte-derived TolDCs from RA patients modulated with dexamethasone and activated with monophosphoryl lipid A (MPLA), referred to as MPLA-tDCs, in t...

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發表在:Front Immunol
Main Authors: García-González, Paulina A., Schinnerling, Katina, Sepúlveda-Gutiérrez, Alejandro, Maggi, Jaxaira, Hoyos, Lorena, Morales, Rodrigo A., Mehdi, Ahmed M., Nel, Hendrik J., Soto, Lilian, Pesce, Bárbara, Molina, María Carmen, Cuchacovich, Miguel, Larrondo, Milton L., Neira, Óscar, Catalán, Diego Francisco, Hilkens, Catharien M., Thomas, Ranjeny, Verdugo, Ricardo A., Aguillón, Juan C.
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2016
主題:
Immunology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078319/
https://ncbi.nlm.nih.gov/pubmed/27826300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00458
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