Treatment with Dexamethasone and Monophosphoryl Lipid A Removes Disease-Associated Transcriptional Signatures in Monocyte-Derived Dendritic Cells from Rheumatoid Arthritis Patients and Confers Tolerogenic Features

Tolerogenic dendritic cells (TolDCs) are promising tools for therapy of autoimmune diseases, such as rheumatoid arthritis (RA). Here, we characterize monocyte-derived TolDCs from RA patients modulated with dexamethasone and activated with monophosphoryl lipid A (MPLA), referred to as MPLA-tDCs, in t...

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Gepubliceerd in:Front Immunol
Hoofdauteurs: García-González, Paulina A., Schinnerling, Katina, Sepúlveda-Gutiérrez, Alejandro, Maggi, Jaxaira, Hoyos, Lorena, Morales, Rodrigo A., Mehdi, Ahmed M., Nel, Hendrik J., Soto, Lilian, Pesce, Bárbara, Molina, María Carmen, Cuchacovich, Miguel, Larrondo, Milton L., Neira, Óscar, Catalán, Diego Francisco, Hilkens, Catharien M., Thomas, Ranjeny, Verdugo, Ricardo A., Aguillón, Juan C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2016
Onderwerpen:
Immunology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078319/
https://ncbi.nlm.nih.gov/pubmed/27826300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00458
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