Treatment with Dexamethasone and Monophosphoryl Lipid A Removes Disease-Associated Transcriptional Signatures in Monocyte-Derived Dendritic Cells from Rheumatoid Arthritis Patients and Confers Tolerogenic Features

Tolerogenic dendritic cells (TolDCs) are promising tools for therapy of autoimmune diseases, such as rheumatoid arthritis (RA). Here, we characterize monocyte-derived TolDCs from RA patients modulated with dexamethasone and activated with monophosphoryl lipid A (MPLA), referred to as MPLA-tDCs, in t...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: García-González, Paulina A., Schinnerling, Katina, Sepúlveda-Gutiérrez, Alejandro, Maggi, Jaxaira, Hoyos, Lorena, Morales, Rodrigo A., Mehdi, Ahmed M., Nel, Hendrik J., Soto, Lilian, Pesce, Bárbara, Molina, María Carmen, Cuchacovich, Miguel, Larrondo, Milton L., Neira, Óscar, Catalán, Diego Francisco, Hilkens, Catharien M., Thomas, Ranjeny, Verdugo, Ricardo A., Aguillón, Juan C.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078319/
https://ncbi.nlm.nih.gov/pubmed/27826300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00458
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