Loss of PAX8 in high-grade serous ovarian cancer reduces cell survival despite unique modes of action in the fallopian tube and ovarian surface epithelium

High-grade serous carcinoma (HGSC) is the most common and lethal form of ovarian cancer. PAX8 is a transcription factor expressed in fallopian tube epithelial cells and in 80–96% of HGSC tumors. The ovarian surface epithelium (OSE) only acquires PAX8 expression after malignant transformation. In thi...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Rodgers, Laura H., hAinmhire, Eoghainín Ó, Young, Alexandria N., Burdette, Joanna E.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078051/
https://ncbi.nlm.nih.gov/pubmed/27129161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9051
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