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Repurposed drug screen identifies cardiac glycosides as inhibitors of TGF-β-induced cancer-associated fibroblast differentiation

The tumor microenvironment, primarily composed of myofibroblasts, directly influences the progression of solid tumors. Through secretion of growth factors, extracellular matrix deposition, and contractile mechanotransduction, myofibroblasts, or cancer-associated fibroblasts (CAFs), support angiogene...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Coleman, David T., Gray, Alana L., Stephens, Charles A., Scott, Matthew L., Cardelli, James A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078007/
https://ncbi.nlm.nih.gov/pubmed/27058757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8609
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