Heterotaxin: a novel TGF-β signaling inhibitor identified in a multi-phenotype profiling screen in Xenopus embryos

Disruptions of anatomical left-right asymmetry result in life-threatening heterotaxic birth defects in vital organs. We performed a small molecule screen for left-right asymmetry phenotypes in Xenopus embryos and discovered a novel pyridine analog, heterotaxin, which disrupts both cardiovascular and...

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Hauptverfasser: Dush, Michael K., McIver, Andrew L., Parr, Meredith A., Young, Douglas D., Fisher, Julie, Newman, Donna R., Sannes, Philip L., Hauck, Marlene L., Deiters, Alexander, Nascone-Yoder, Nanette
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3050558/
https://ncbi.nlm.nih.gov/pubmed/21338922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.12.008
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