Lysyl oxidase family activity promotes resistance of pancreatic ductal adenocarcinoma to chemotherapy by limiting the intratumoral anticancer drug distribution

Solid tumors often display chemotherapy resistance. Pancreatic ductal adenocarcinoma (PDAC) is the archetype of resistant tumors as current chemotherapies are inefficient. The tumor stroma and extracellular matrix (ECM) are key contributors to PDAC aggressiveness and to limiting the efficacy of chem...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Le Calvé, Benjamin, Griveau, Audrey, Vindrieux, David, Maréchal, Raphaël, Wiel, Clotilde, Svrcek, Magali, Gout, Johann, Azzi, Lamia, Payen, Léa, Cros, Jérôme, de la Fouchardière, Christelle, Dubus, Pierre, Guitton, Jérôme, Bartholin, Laurent, Bachet, Jean-Baptiste, Bernard, David
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078000/
https://ncbi.nlm.nih.gov/pubmed/27050073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8527
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