Cancer-selective cytotoxic Ca(2+) overload in acute myeloid leukemia cells and attenuation of disease progression in mice by synergistically acting polyphenols curcumin and carnosic acid

Acute myeloid leukemia (AML) is an aggressive hematologic malignancy characterized by extremely heterogeneous molecular and biologic abnormalities that hamper the development of effective targeted treatment modalities. While AML cells are highly sensitive to cytotoxic Ca(2+) overload, the feasibilit...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Pesakhov, Stella, Nachliely, Matan, Barvish, Zeev, Aqaqe, Nasma, Schwartzman, Bar, Voronov, Elena, Sharoni, Yoav, Studzinski, George P., Fishman, Daniel, Danilenko, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5077981/
https://ncbi.nlm.nih.gov/pubmed/26870993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7240
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