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Shared gamma(c) subunit within the human interleukin-7 receptor complex. A molecular basis for the pathogenesis of X-linked severe combined immunodeficiency.

Genetic evidence suggests that mutations in the gamma(c) receptor subunit cause X-linked severe combined immunodeficiency (X-SCID). The gamma(c) subunit can be employed in receptor complexes for IL-2, -4, -7, -9, and -15, and the multiple signaling defects that would result from a defective gamma(c)...

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Bibliografske podrobnosti
izdano v:J Clin Invest
Main Authors: Lai, S Y, Molden, J, Goldsmith, M A
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 1997
Teme:
Online dostop:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507783/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9005984/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119144
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