A COL11A1-correlated pan-cancer gene signature of activated fibroblasts for the prioritization of therapeutic targets

Although cancer-associated fibroblasts (CAFs) are viewed as a promising therapeutic target, the design of rational therapy has been hampered by two key obstacles. First, attempts to ablate CAFs have resulted in significant toxicity because currently used biomarkers cannot effectively distinguish act...

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Detalhes bibliográficos
Publicado no:Cancer Lett
Main Authors: Jia, Dongyu, Liu, Zhenqiu, Deng, Nan, Tan, Tuan Zea, Huang, Ruby Yun-Ju, Taylor-Harding, Barbie, Cheon, Dong-Joo, Lawrenson, Kate, Wiedemeyer, Wolf R., Walts, Ann E., Karlan, Beth Y., Orsulic, Sandra
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5077659/
https://ncbi.nlm.nih.gov/pubmed/27609069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2016.09.001
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