Sphingosine kinase 1 is required for TGF-β mediated fibroblast-to-myofibroblast differentiation in ovarian cancer

Sphingosine kinase 1 (SPHK1), the enzyme that produces sphingosine 1 phosphate (S1P), is known to be highly expressed in many cancers. However, the role of SPHK1 in cells of the tumor stroma remains unclear. Here, we show that SPHK1 is highly expressed in the tumor stroma of high-grade serous ovaria...

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Podrobná bibliografie
Vydáno v:Oncotarget
Hlavní autoři: Beach, Jessica A., Aspuria, Paul-Joseph P., Cheon, Dong-Joo, Lawrenson, Kate, Agadjanian, Hasmik, Walsh, Christine S., Karlan, Beth Y., Orsulic, Sandra
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826197/
https://ncbi.nlm.nih.gov/pubmed/26716409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6703
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