Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate-mediated pathway. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors.

During chronic liver diseases, hepatic stellate cells (HSC) acquire an activated myofibroblast-like phenotype, proliferate, and synthetize fibrosis components. We have shown that endothelin-1 (ET-1) inhibits the proliferation of activated human HSC via endothelin B (ETB) receptors. We now investigat...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Mallat, A, Préaux, A M, Serradeil-Le Gal, C, Raufaste, D, Gallois, C, Brenner, D A, Bradham, C, Maclouf, J, Iourgenko, V, Fouassier, L, Dhumeaux, D, Mavier, P, Lotersztajn, S
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1996
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507742/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8981923/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119103
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