Towards Development of Small Molecule Lipid II Inhibitors as Novel Antibiotics

Recently we described a novel di-benzene-pyrylium-indolene (BAS00127538) inhibitor of Lipid II. BAS00127538 (1-Methyl-2,4-diphenyl-6-((1E,3E)-3-(1,3,3-trimethylindolin-2-ylidene)prop-1-en-1-yl)pyryl-1-ium) tetrafluoroborate is the first small molecule Lipid II inhibitor and is structurally distinct...

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Pubblicato in:PLoS One
Autori principali: Chauhan, Jamal, Cardinale, Steven, Fang, Lei, Huang, Jing, Kwasny, Steven M., Pennington, M. Ross, Basi, Kelly, diTargiani, Robert, Capacio, Benedict R., MacKerell, Alexander D., Opperman, Timothy J., Fletcher, Steven, de Leeuw, Erik P. H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5077133/
https://ncbi.nlm.nih.gov/pubmed/27776124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164515
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