Expression of Death Receptor 4 Is Positively Regulated by MEK/ERK/AP-1 Signaling and Suppressed upon MEK Inhibition

Death receptor 4 (DR4) is a cell surface receptor for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and triggers apoptosis upon ligation with TRAIL or aggregation. MEK/ERK signaling is a well known and the best-studied effector pathway downstream of Ras and Raf. This study focuses...

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Publicado en:J Biol Chem
Autores principales: Yao, Weilong, Oh, You-Take, Deng, Jiusheng, Yue, Ping, Deng, Liang, Huang, Henry, Zhou, Wei, Sun, Shi-Yong
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076838/
https://ncbi.nlm.nih.gov/pubmed/27576686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.738302
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