Inhibition of B-Raf/MEK/ERK signaling suppresses DR5 expression and impairs response of cancer cells to DR5-mediated apoptosis and T cell-induced killing

Inhibition of B-Raf/MEK/ERK signaling is an effective therapeutic strategy against certain types of cancers such as melanoma and thyroid cancer. While demonstrated to be effective anticancer agents, B-Raf or MEK inhibitors have also been associated with early tumor progression and development of sec...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Oh, You-Take, Deng, Jiusheng, Yue, Ping, Owonikoko, Taofeek K., Khuri, Fadlo R., Sun, Shi-Yong
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4604000/
https://ncbi.nlm.nih.gov/pubmed/25867065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.97
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