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Inhibition of B-Raf/MEK/ERK signaling suppresses DR5 expression and impairs response of cancer cells to DR5-mediated apoptosis and T cell-induced killing
Inhibition of B-Raf/MEK/ERK signaling is an effective therapeutic strategy against certain types of cancers such as melanoma and thyroid cancer. While demonstrated to be effective anticancer agents, B-Raf or MEK inhibitors have also been associated with early tumor progression and development of sec...
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Foilsithe in: | Oncogene |
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Main Authors: | , , , , , |
Formáid: | Artigo |
Teanga: | Inglês |
Foilsithe: |
2015
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Ábhair: | |
Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4604000/ https://ncbi.nlm.nih.gov/pubmed/25867065 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.97 |
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