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Oncogenic Ras and B-Raf Proteins Positively Regulate Death Receptor 5 Expression through Co-activation of ERK and JNK Signaling

Oncogenic mutations of ras and B-raf frequently occur in many cancer types and are critical for cell transformation and tumorigenesis. Death receptor 5 (DR5) is a cell surface pro-apoptotic death receptor for tumor necrosis factor-related apoptosis-inducing ligand and has been targeted in cancer the...

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Библиографические подробности
Главные авторы: Oh, You-Take, Yue, Ping, Zhou, Wei, Balko, Justin M., Black, Esther P., Owonikoko, Taofeek K., Khuri, Fadlo R., Sun, Shi-Yong
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249076/
https://ncbi.nlm.nih.gov/pubmed/22065586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.304006
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