Melanoma Differentiation-associated Gene 7/IL-24 Exerts Cytotoxic Effects by Altering the Alternative Splicing of Bcl-x Pre-mRNA via the SRC/PKCδ Signaling Axis

Melanoma differentiation-associated gene 7 (MDA-7/IL-24) exhibits cytotoxic effects on tumor cells while sparing untransformed cells, and Bcl-x(L) is reported to efficiently block the induction of cell death by MDA-7/IL-24. The expression of Bcl-x(L) is regulated at the level of RNA splicing via alt...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Shapiro, Brian A., Vu, Ngoc T., Shultz, Michael D., Shultz, Jacqueline C., Mietla, Jennifer A., Gouda, Mazen M., Yacoub, Adly, Dent, Paul, Fisher, Paul B., Park, Margaret A., Chalfant, Charles E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076836/
https://ncbi.nlm.nih.gov/pubmed/27519412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.737569
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