Melanoma Differentiation-associated Gene 7/IL-24 Exerts Cytotoxic Effects by Altering the Alternative Splicing of Bcl-x Pre-mRNA via the SRC/PKCδ Signaling Axis

Melanoma differentiation-associated gene 7 (MDA-7/IL-24) exhibits cytotoxic effects on tumor cells while sparing untransformed cells, and Bcl-x(L) is reported to efficiently block the induction of cell death by MDA-7/IL-24. The expression of Bcl-x(L) is regulated at the level of RNA splicing via alt...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Shapiro, Brian A., Vu, Ngoc T., Shultz, Michael D., Shultz, Jacqueline C., Mietla, Jennifer A., Gouda, Mazen M., Yacoub, Adly, Dent, Paul, Fisher, Paul B., Park, Margaret A., Chalfant, Charles E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076836/
https://ncbi.nlm.nih.gov/pubmed/27519412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.737569
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