C4b-binding Protein Protects β-Cells from Islet Amyloid Polypeptide-induced Cytotoxicity

C4BP (C4b-binding protein) is a polymer of seven identical α chains and one unique β chain synthesized in liver and pancreas. We showed previously that C4BP enhances islet amyloid polypeptide (IAPP) fibril formation in vitro. Now we report that polymeric C4BP strongly inhibited lysis of human erythr...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Sjölander, Jonatan, Byman, Elin, Kulak, Klaudia, Nilsson, Sara C., Zhang, Enming, Krus, Ulrika, Westermark, Gunilla T., Storm, Petter, King, Ben C., Renström, Erik, Blom, Anna M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076834/
https://ncbi.nlm.nih.gov/pubmed/27566545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.731141
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