Islet Amyloid Polypeptide Triggers Limited Complement Activation and Binds Complement Inhibitor C4b-binding Protein, Which Enhances Fibril Formation

Islet amyloid polypeptide (IAPP) is synthesized in pancreatic β-cells and co-secreted with insulin. Aggregation and formation of IAPP-amyloid play a critical role in β-cell death in type 2 diabetic patients. Because Aβ-fibrils in Alzheimer disease activate the complement system, we have here investi...

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Bibliographic Details
Main Authors: Sjölander, Jonatan, Westermark, Gunilla T., Renström, Erik, Blom, Anna M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322885/
https://ncbi.nlm.nih.gov/pubmed/22334700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.244285
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