The Breast Cancer Tumor Suppressor TRIM29 Is Expressed via ATM-dependent Signaling in Response to Hypoxia

Reduced ATM function has been linked to breast cancer risk, and the TRIM29 protein is an emerging breast cancer tumor suppressor. Here we show that, in cultured breast tumor and non-tumorigenic mammary epithelial cells, TRIM29 is up-regulated in response to hypoxic stress but not DNA damage. Hypoxia...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Dükel, Muzaffer, Streitfeld, W. Scott, Tang, Tsz Ching Chloe, Backman, Lindsey R. F., Ai, Lingbao, May, W. Stratford, Brown, Kevin D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076825/
https://ncbi.nlm.nih.gov/pubmed/27535224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.730960
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