Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain

Insulin and insulin-like growth factors I and II are closely related protein hormones. Their distinct evolution has resulted in different yet overlapping biological functions with insulin becoming a key regulator of metabolism, whereas insulin-like growth factors (IGF)-I/II are major growth factors....

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Hexnerová, Rozálie, Křížková, Květoslava, Fábry, Milan, Sieglová, Irena, Kedrová, Kateřina, Collinsová, Michaela, Ullrichová, Pavlína, Srb, Pavel, Williams, Christopher, Crump, Matthew P., Tošner, Zdeněk, Jiráček, Jiří, Veverka, Václav, Žáková, Lenka
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076530/
https://ncbi.nlm.nih.gov/pubmed/27510031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.741041
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