Binding Sites for Acylated Trehalose Analogs of Glycolipid Ligands on an Extended Carbohydrate Recognition Domain of the Macrophage Receptor Mincle

The macrophage receptor mincle binds to trehalose dimycolate on the surface of Mycobacterium tuberculosis. Signaling initiated by this interaction leads to cytokine production, which underlies the ability of mycobacteria to evade the immune system and also to function as adjuvants. In previous work...

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Vydáno v:J Biol Chem
Hlavní autoři: Feinberg, Hadar, Rambaruth, Neela D. S., Jégouzo, Sabine A. F., Jacobsen, Kristian M., Djurhuus, Rasmus, Poulsen, Thomas B., Weis, William I., Taylor, Maureen E., Drickamer, Kurt
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Glycobiology and Extracellular Matrices
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076529/
https://ncbi.nlm.nih.gov/pubmed/27542410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.749515
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