The natural product brartemicin is a high affinity ligand for the carbohydrate-recognition domain of the macrophage receptor mincle

We demonstrate that the natural product brartemicin, a newly discovered inhibitor of cancer cell invasion, is a high-affinity ligand of the carbohydrate-recognition domain (CRD) of the C-type lectin mincle. Recent studies have revealed that mincle is a key macrophage receptor for the mycobacterial v...

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Publicado en:Medchemcomm
Autores principales: Jacobsen, Kristian M., Keiding, Ulrik B., Clement, Lise L., Schaffert, Eva S., Rambaruth, Neela D. S., Johannsen, Mogens, Drickamer, Kurt, Poulsen, Thomas B.
Formato: Artigo
Lenguaje:Inglês
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4393326/
https://ncbi.nlm.nih.gov/pubmed/25893085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4md00512k
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