The antifungal antibiotic, clotrimazole, inhibits Cl- secretion by polarized monolayers of human colonic epithelial cells.

Clotrimazole (CLT) prevents dehydration of the human HbSS red cell through inhibition of Ca++-dependent (Gardos) K+ channels in vitro (1993. J. Clin Invest. 92:520-526.) and in patients (1996. J. Clin Invest. 97:1227-1234.). Basolateral membrane K+ channels of intestinal crypt epithelial cells also...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Rufo, P A, Jiang, L, Moe, S J, Brugnara, C, Alper, S L, Lencer, W I
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507651/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8903326/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119012
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