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The antifungal antibiotic, clotrimazole, inhibits Cl- secretion by polarized monolayers of human colonic epithelial cells.

Clotrimazole (CLT) prevents dehydration of the human HbSS red cell through inhibition of Ca++-dependent (Gardos) K+ channels in vitro (1993. J. Clin Invest. 92:520-526.) and in patients (1996. J. Clin Invest. 97:1227-1234.). Basolateral membrane K+ channels of intestinal crypt epithelial cells also...

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Publicat a:J Clin Invest
Autors principals: Rufo, P A, Jiang, L, Moe, S J, Brugnara, C, Alper, S L, Lencer, W I
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 1996
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507651/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8903326/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119012
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