Prevention of adoptively transferred diabetes in nonobese diabetic mice with IL-10-transduced islet-specific Th1 lymphocytes. A gene therapy model for autoimmune diabetes.

Four pancreatic islet-specific CD4+ helper T (Th) 1 (Th1) clones and two Th1 clones transduced with an SRalpha promoter-linked murine IL-10 (mIL-10) cDNA of 2.0-6.0 x 10(6) cells were adoptively transferred to nonobese diabetic (NOD) mice at age 8 d. Cyclophosphamide (CY) was administered at age 37...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Moritani, M, Yoshimoto, K, Ii, S, Kondo, M, Iwahana, H, Yamaoka, T, Sano, T, Nakano, N, Kikutani, H, Itakura, M
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1996
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507625/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8878437/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118986
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