Demonstration of an osteoblast defect in two cases of human malignant osteopetrosis. Correction of the phenotype after bone marrow transplant.

Osteopetrosis is an inherited disorder characterized by bone sclerosis due to reduced bone resorption. Here we report that human osteopetrotic osteoblast-like (Ob) cells express a defective phenotype in primary cultures in vitro, and that bone marrow transplant (BMT) corrects osteoblast function. DN...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Lajeunesse, D, Busque, L, Ménard, P, Brunette, M G, Bonny, Y
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507623/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8878435/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118984
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