Demonstration of an osteoblast defect in two cases of human malignant osteopetrosis. Correction of the phenotype after bone marrow transplant.

Osteopetrosis is an inherited disorder characterized by bone sclerosis due to reduced bone resorption. Here we report that human osteopetrotic osteoblast-like (Ob) cells express a defective phenotype in primary cultures in vitro, and that bone marrow transplant (BMT) corrects osteoblast function. DN...

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Pubblicato in:	J Clin Invest
Autori principali:	Lajeunesse, D, Busque, L, Ménard, P, Brunette, M G, Bonny, Y
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507623/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8878435/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118984
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