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Muscle wasting in insulinopenic rats results from activation of the ATP-dependent, ubiquitin-proteasome proteolytic pathway by a mechanism including gene transcription.

In normal subjects and diabetic patients, insulin suppresses whole body proteolysis suggesting that the loss of lean body mass and muscle wasting in insulinopenia is related to increased muscle protein degradation. To document how insulinopenia affects organ weights and to identify the pathway for a...

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Published in:J Clin Invest
Main Authors: Price, S R, Bailey, J L, Wang, X, Jurkovitz, C, England, B K, Ding, X, Phillips, L S, Mitch, W E
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1996
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507607/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8878419/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118968
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