The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction

Barrier dysfunction is a characteristic of the inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis. Understanding how the tight junction is modified to maintain barrier function may provide avenues for treatment of IBD. We have previously shown that the apical addition of...

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Détails bibliographiques
Publié dans:Am J Physiol Gastrointest Liver Physiol
Auteurs principaux: Ronaghan, Natalie J., Shang, Judie, Iablokov, Vadim, Zaheer, Raza, Colarusso, Pina, Dion, Sébastien, Désilets, Antoine, Leduc, Richard, Turner, Jerrold R., MacNaughton, Wallace K.
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2016
Sujets:
Epithelial Biology and Secretion
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076006/
https://ncbi.nlm.nih.gov/pubmed/27492333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00441.2015
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