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αβ T cell receptor germline CDR regions moderate contact with MHC ligands and regulate peptide cross-reactivity
αβ T cells respond to peptide epitopes presented by major histocompatibility complex (MHC) molecules. The role of T cell receptor (TCR) germline complementarity determining regions (CDR1 and 2) in MHC restriction is not well understood. Here, we examine T cell development, MHC restriction and antige...
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| Pubblicato in: | Sci Rep |
|---|---|
| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5075794/ https://ncbi.nlm.nih.gov/pubmed/27775030 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35006 |
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