The T-cell receptor is not hardwired to engage MHC ligands

The bias of αβ T cells for MHC ligands has been proposed to be intrinsic to the T-cell receptor (TCR). Equally, the CD4 and CD8 coreceptors contribute to ligand restriction by colocalizing Lck with the TCR when MHC ligands are engaged. To determine the importance of intrinsic ligand bias, the germ-l...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Holland, Stephen J., Bartok, Istvan, Attaf, Meriem, Genolet, Raphael, Luescher, Immanuel F., Kotsiou, Eleni, Richard, Ashkenaz, Wang, Edward, White, Matthew, Coe, David J., Chai, Jian-Guo, Ferreira, Cristina, Dyson, Julian
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2012
Pynciau:
PNAS Plus
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494948/
https://ncbi.nlm.nih.gov/pubmed/23077253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1210882109
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