Synthetic oligonucleotide antigens modified with locked nucleic acids detect disease specific antibodies

New techniques to detect and quantify antibodies to nucleic acids would provide a significant advance over current methods, which often lack specificity. We investigate the potential of novel antigens containing locked nucleic acids (LNAs) as targets for antibodies. Particularly, employing molecular...

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Udgivet i:Sci Rep
Main Authors: Samuelsen, Simone V., Solov’yov, Ilia A., Balboni, Imelda M., Mellins, Elizabeth, Nielsen, Christoffer Tandrup, Heegaard, Niels H. H., Astakhova, Kira
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5075775/
https://ncbi.nlm.nih.gov/pubmed/27775006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35827
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